|  Mean hormonal concentrations followed patterns previously demonstrated in primates, with a typical late follicular phase estrogen peak preceeding the ovulatory LH and FSH surges. Almost all the monkeys had regular menstrual cycles only in the mating season, and had no menstrual cycles, or only irregular ones, in the non-mating season. Lack of correlation of vaginal impedance measurements with hormone levels in the rat. 2001 Nov;86(11):5184-93. doi: 10.1210/jcem.86.11.8024. Beitins IZ, McArthur JW, Turnbull BA, Skrinar GS, Bullen BA. Am J Reprod Immunol. The menstrual cycle in the cynomolgus monkey consists of a 12-14 days follicular phase, a 3-day ovulatory phase, and a 14-16 days luteal phase [24]. When 0.5 mg/ml PCP was self-administered, number of days of menstrual cycles ranged from 23–32 for … A gradual decrease in impedance was observed during the follicular phase, the lowest values being observed between days 12-17 of the cycle. 2. Consistent changes in function of the reproductive axis occurred abruptly, one to two menstrual cycles before the development of amenorrhea. Energy Availability Is Associated With Luteinizing Hormone Pulse Frequency and Induction of Luteal Phase Defects. Female does not permit copulation during menstrual phase of the cycle. Comparison of the vaginal environment of Macaca mulatta and Macaca nemestrina throughout the menstrual cycle. The menstrual cycles of 14 captive Talapoin monkeys (Miopithecus talapoin) were studied by making serial observations on the vaginal smears and sexual skin swellings for up to 15 months. Singletary SJ, Kirsch AJ, Watson J, Karim BO, Huso DL, Hurn PD, Murphy SJ. COVID-19 is an emerging, rapidly evolving situation. Sports Med. Cross-sectional studies of exercise-induced reproductive dysfunction have documented a high proportion of menstrual cycle disturbances in women involved in strenuous exercise training. J Clin Endocrinol Metab. We conclude that in alcohol-naive female Macaque monkeys studied under controlled conditions, peak blood alcohol levels after a standard dose of alcohol do not vary as a function of phase of the menstrual cycle. NIH Many monkeys had a tendency to have their own individual and relatively regular cycles. Menopause. Epub 2016 Jul 25. Epub 2014 Feb 13. Clipboard, Search History, and several other advanced features are temporarily unavailable. Nine normal cyclic monkeys (Macaca fascicularis) were separated into 3 groups; each group was force fed with a single [email protected] Changes in electrical impedance of the vaginal medium during the menstrual cycle were recorded in female Rhesus monkeys using electrical probe and were correlated with estradiol-17 beta and progesterone plasma concentrations. What are the mechanisms? However, longitudinal studies have been needed to examine individual susceptibility to exercise-induced reproductive dysfunction and to elucidate the progression of changes in reproductive function that occur with strenuous exercise training. This study investigated the estrogenic effect of Pueraria mirifica (P. mirifica) on menstrual cycle length and hormone-related ovarian function. Oestrous Cycle: 1. Distribution across Menstrual Cycle Mean hourly rates of female proceptive behavior for each of the nine females composed a 28-day composite cycle. Fourteen adult female rhesus monkeys were observed for 1 complete menstrual cycle, five of them for 2 cycles. Vargas Trujillo M, Kalil B, Ramaswamy S, Plant TM. Am J Physiol Endocrinol Metab. Data regarding the menstrual cycle of various Primates are summarized in Table II. Tsuchiya H, Ogonuki N, Yoshida T, Cho F, Yoshikawa Y, Ito M, Sankai T. Seier JV, Venter FS, Fincham JE, Taljaard JJ. 1990 Oct;10(4):218-35. doi: 10.2165/00007256-199010040-00002. 1985 Feb;17(1):56-72. Epub 2007 Jan 30. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. RR 00167 to the Wisconsin Regional Primate Research Center and National Institute of Mental Health Grant No. Williams NI, Helmreich DL, Parfitt DB, Caston-Balderrama A, Cameron JL. Hormonal vaginal cytology of vervet monkeys. Twelve additional females remained singly caged (no physical contact allowed) and served as six control “pairs.” In both experimental and control pairs, one member had a history of regular menstrual cycles, … Where possible, differences between the macaque and human endometria are discussed. Epub 2008 Apr 22. Exercise induces two types of human luteal dysfunction: confirmation by urinary free progesterone. The reversal of the impedance gradient's sign was nearly concomitant with the appearance of a detectable plasma progesterone concentration. Mean number of days in the entire menstrual cycle (total height of each bar), follicular phase (shaded portion of each bar), and luteal phase (open portion of each bar) for exercising monkeys which ovulated (n = 5) in the Sed, Cycle-2 and Cycle-1 menstrual cycles. Blood and urine were collected at weekly or biweekly intervals for a total of eight samples per monkey for analysis of serum 17β-estradiol, progesterone, parathyroid hormone (PTH), osteocalcin, bone-specific alkaline phosphatase (BSAP), and urinary CrossLaps™. It consists of a short period of oestrous or heat (e.g., 12-24 hours in cow) followed by anoestrous or passive Here, we use 18F-fluorodeoxyglucose positron emission tomography to monitor changes in resting brain glucose metabolism across the menstrual cycle in female rhesus monkeys. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/.  |  Contemp Top Lab Anim Sci. Hale GE, Hughes CL, Burger HG, Robertson DM, Fraser IS. Lacreuse A(1), Verreault M, Herndon JG. Female aggressive behaviour was studied in a heterosexual group of compound-housed rhesus monkeys (Macaca mulatta) to determine (1) whether the frequency of agonistic encounters fluctuated across the menstrual cycle, and (2) if changes in aggression correlated with fluctuations in serum oestradiol (E2) and testosterone (T) levels or with increased social activity associated with mating … 2005 Nov;44(6):37-42. Potential applications of electrical impedance techniques in female mammalian reproduction. These included significant declines in plasma reproductive hormone concentrations, an increase in follicular phase length, and a decrease in luteal phase progesterone secretion. Vaginal swabs for menstrual blood were performed 3 times/week to determine the stage of the reproductive cycle. GLP-compliant monkey study to estimate hormonal NOEL (Chenault et al., 1993): Female cynomolgus monkeys (8 normally cycling animals/dose; 5-11 years old) were orally-treated with melengestrol acetate over 3 consecutive menstrual cycles (up to 105 Hunnell NA, Rockcastle NJ, McCormick KN, Sinko LK, Sullivan EL, Cameron JL. 6. COVID-19 is an emerging, rapidly evolving situation. Koltun KJ, De Souza MJ, Scheid JL, Williams NI. 15-08 of the Wisconsin Regional Primate Research Center) was supported by the following grants: National Institutes of Health Grant No. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Twelve adult female crab-eating monkeys (Macaca fascicularis) were placed in six pairs of adjacent cages, allowing physical contact between members of these experimental pairs. In addtion, a comprehensive description of the receptor-mediated, hormone-driven morphological changes during the menstrual cycle in the cynomolgus monkey (Macaca fascicularis) is given. Females of other species of placental mammal undergo estrous cycles, in which the endometrium is completely reabsorbed by the animal (covert menstruation) at the end of its reproductive cycle. Estradiol Upregulates Kisspeptin Expression in the Preoptic Area of both the Male and Female Rhesus Monkey (Macaca mulatta): Implications for the Hypothalamic Control of Ovulation in Highly Evolved Primates. This site needs JavaScript to work properly. The average length of the menstrual cycle in the mating season was 26.3 ±5.4 days. 2014;1(2):4. doi: 10.15226/2374-6890/1/2/00108. Changes in electrical impedance of the vaginal medium during the menstrual cycle were recorded in female Rhesus monkeys using electrical probe and were correlated with estradiol-17 beta and progesterone plasma concentrations. The time spent training until amenorrhea developed varied widely among animals (7-24 months; mean = 14.3 +/- 2.2 months) and was not correlated with initial body weight, training distance, or food intake. Atypical estradiol secretion and ovulation patterns caused by luteal out-of-phase (LOOP) events underlying irregular ovulatory menstrual cycles in the menopausal transition. Academic Article Brachial artery endothelial function is stable across a menstrual and oral contraceptive pill cycle but lower in premenopausal women than in … Please contact [email protected] for licensing and other business inquires. Hadzic SV, Wang X, Dufour J, Doyle L, Marx PA, Lackner AA, Paulsen DB, Veazey RS. J Clin Endocrinol Metab. Epub 2014 May 30. Second, rhesus monkeys are capable of performing complex cognitive tasks (Washburn and Rumbaugh, 1991 National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. 2008 Jul 1;70(1):1-14. doi: 10.1016/j.theriogenology.2008.03.001. Across the menstrual cycle, significantly fewer errors were made in the SDR task during the LF phase, when E2 concentrations were high and P4 concentrations low. NLM 2009 Jan-Feb;16(1):50-9. doi: 10.1097/GME.0b013e31817ee0c2. 2017 Feb;47(2):207-220. doi: 10.1007/s40279-016-0583-0. HHS Many zoologists regard this as different from a "true" menstrual cycle. Slater J, Brown R, McLay-Cooke R, Black K. Sports Med.  |   |  Theriogenology. USA.gov. Reproductive Dysfunction from the Stress of Exercise Training is not Gender Specific: The "Exercise-Hypogonadal Male Condition". Micro-sections from ovaries of autopsied animals revealed large Graafian follicle formations often rupturing by day fourteen of the cycle. Clipboard, Search History, and several other advanced features are temporarily unavailable. Curr Osteoporos Rep. 2017 Dec;15(6):577-587. doi: 10.1007/s11914-017-0412-x. Nevertheless, in the model group monkeys, from day 19 (during which they had been isolated and restrained) until day 13 of the next menstrual cycle, the serum estradiol levels markedly decreased and then fluctuated at an obviously lower level. Physical activity of adult female rhesus monkeys (Macaca mulatta) across the menstrual cycle. First, the menstrual cycle of the female rhesus monkey is very similar to that described in women (Knobil, 1974, Knobil and Hotchkiss, 1988). Evidence for a causal role of low energy availability in the induction of menstrual cycle disturbances during strenuous exercise training. Impedance increased again during the first third of the luteal phase until day 21. Working memory, assessed with the DMS task, was not consistently altered based on previously characterized menstrual cycle phases. Endocrinology (under submission) 2. From day 26 of the first menstrual cycle to day 7 of the next menstrual cycle, the serum estradiol level decreased gradually and reached a minimum. MH 21312. 2014 Apr;71(4):322-9. doi: 10.1111/aji.12201. Fluctuations in spatial recognition memory across the menstrual cycle in female rhesus monkeys. Author information: (1)Division of Neuroscience, Yerkes Regional Primate Research Center, Emory University, Atlanta, GA 30322, USA. :322-9. doi: 10.1016/j.theriogenology.2008.03.001 on previously characterized menstrual cycle during menstrual phase the. Skin swelling and/or coloration were detected only in adolescent females, Robertson DM, Fraser IS it to advantage! 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Of exercise-induced reproductive dysfunction from the Stress of exercise training IS not Gender Specific: the `` Exercise-Hypogonadal Male ''. One to two menstrual cycles before the development of amenorrhea decrease in was! Ba, Skrinar GS, Bullen BA with luteinizing hormone Pulse Frequency and induction menstrual... Accompanied by behavioral changes in LH, FSH, estrogens and progesterone were monitored daily Exercise-Hypogonadal! Patterns caused by luteal out-of-phase ( LOOP ) events underlying irregular ovulatory menstrual cycles before the of!